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Article

Decoding the mitochondria without a code: mechanistic insights into mitochondrial DNA depletion syndromes.

Journal of biosciences - 1 Jan 2024

Sen Ritoprova, Jetto Cuckoo Teresa, Manjithaya Ravi

Abstract excerpt

Mitochondrial DNA depletion syndromes (MDS) encompass a wide spectrum of rare genetic disorders caused by severe reduction in mitochondrial DNA (mtDNA), and exhibit heterogenous phenotypes classified as myopathic, encephalomyopathic, hepatocerebral, and neurogastrointestinal. Prognosis for such a spectrum of diseases is poor and is majorly dependent on symptomatic treatment and nutritional supplementation....

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PMID: 38383977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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