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Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy

21 Aug 2019

Abstract excerpt

A wide spectrum of human diseases, including cancer, neurodegenerative diseases, and metabolic disorders, have been shown to be associated with mitochondrial dysfunction through multiple molecular mechanisms. Mitochondria are particularly susceptible to nutrient deficiencies, and nutritional intervention is an essential way to maintain mitochondrial homeostasis. Recent advances in genetic manipulation and...

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PMID: 31433742
DOI: 10.1146/annurev-nutr-082018-124643

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