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Article

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.

Cell death and differentiation - 1 Nov 2017

Piyush Tushar, Chacko Anisha R, Sindrewicz Paulina, Hilkens John, Rhodes Jonathan M, Yu Lu-Gang

Abstract excerpt

Epidermal growth factor receptor (EGFR) is an important regulator of epithelial cell growth and survival in normal and cancerous tissues and is a principal therapeutic target for cancer treatment. EGFR is associated in epithelial cells with the heavily glycosylated transmembrane mucin protein MUC1, a natural ligand of galectin-3 that is overexpressed in cancer. This study reveals that the expression of cell...

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Source

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Identifiers

PMID: 28731466
DOI: 10.1038/cdd.2017.119
PMCID: PMC5635220

Genes

EGFR
MUC1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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