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Article

The burden of rare protein-truncating genetic variants on human lifespan.

Nature aging - 1 Apr 2022

Liu Jimmy Z, Chen Chia-Yen, Tsai Ellen A, Whelan Christopher D, Sexton David, John Sally, Runz Heiko

Abstract excerpt

Genetic predisposition has been shown to contribute substantially to the age at which we die. Genome-wide association studies (GWASs) have linked more than 20 loci to phenotypes related to human lifespan1. However, little is known about how lifespan is impacted by gene loss of function. Through whole-exome sequencing of 352,338 UK Biobank participants of European ancestry, we assessed the relevance of...

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Identifiers

PMID: 37117740
DOI: 10.1038/s43587-022-00182-3
PMCID: PMC10154195

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