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Article

Unveiling chronic spontaneous urticaria pathophysiology through systems biology

29 Dec 2022

Abstract excerpt

BACKGROUND: Chronic spontaneous urticaria (CSU) is a rare, heterogeneous, severely debilitating, and often poorly controlled skin disease resulting in an itchy eruption that can be persistent. Antihistamines and omalizumab, an anti-IgE mAb, are the only licensed therapies. Although CSU pathogenesis is not yet fully understood, mast cell activation through the IgE:high-affinity IgE receptor (FcεRI) axis appears...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36587849
DOI: 10.1016/j.jaci.2022.12.809

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