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Article

High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro

2026-02-26

Abstract excerpt

<h4>Background: </h4> and objectives: The PWWP domain of lens epithelium-derived growth factor p75 (LEDGF/p75) mediates chromatin engagement through recognition of histone H3 lysine 36 di- and trimethylation (H3K36me2/3) and nucleosomal DNA. LEDGF/p75 plays a role in multiple human diseases. In particular, its interaction with HIV-1 integrase enables viral genome integration. However, the LEDGF PWWP domain remains...

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Literature Corpus work
c8c46260-2b99-5328-9fdc-30a567296505
DOI
10.20944/preprints202602.1584.v1
Open publication

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High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In VitroDOI 10.20944/preprints202602.1584.v1
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