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Article

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro

20 Dec 2007

Abstract excerpt

Integration is an essential step in the retroviral lifecycle, and the lentiviral integrase binding protein lens epithelium-derived growth factor (LEDGF)/p75 plays a crucial role during human immunodeficiency virus type 1 (HIV-1) cDNA integration. In vitro, LEDGF/p75 stimulates HIV-1 integrase activity into naked target DNAs. Here, we demonstrate that this chromatin-associated protein also stimulates HIV-1...

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PMID: 18174227
DOI: 10.1093/nar/gkm1127

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Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitroPMID 18174227Read ↗

Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted IntegrationSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZSemantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.Semantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 IntegraseSemantic proximity Read ↗

Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.Semantic proximity Read ↗

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactorSemantic proximity Read ↗

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV InfectionSemantic proximity Read ↗

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