Article

Disabling a key viral innate immunity antagonist converts measles vaccine into RIG-I–driven cancer immunotherapy

2025-10-08

Abstract excerpt

<h4>ABSTRACT</h4> Oncolytic viruses can destroy tumors directly or by activating antitumor immunity, but balancing safety with potent immune stimulation remains challenging. Here, we show that deletion of the measles virus C protein, a key viral antagonist of innate immunity, reprograms the live-attenuated vaccine strain into a RIG-I–driven cancer immunotherapy. The resulting virus, MVdeltaC, accumulates defectiv...

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Literature Corpus work: 60a39b66-5727-5ac9-b2d7-4b78d0240b4c
DOI: 10.1101/2025.10.03.680227

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