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Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination

2 Dec 2015

Abstract excerpt

Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, attenuated MV strains preferentially infect and destroy a wide variety of cancer cells making them...

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PMID: 26631840
DOI: 10.1080/21645515.2015.1122146

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