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Article

Antitumor Virotherapy by Attenuated Measles Virus (MV)

28 Mar 2013

Abstract excerpt

Antitumor virotherapy consists of the use of replication-competent viruses to infect and kill tumor cells preferentially, without damaging healthy cells. Vaccine-attenuated strains of measles virus (MV) are good candidates for this approach. Attenuated MV uses the CD46 molecule as a major entry receptor into cells. This molecule negatively regulates the complement system and is frequently overexpressed by cancer...

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PMID: 24832799
DOI: 10.3390/biology2020587

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