Article

Pathway-based polygenic score analysis identifies the NRF2-KEAP1 and mRNA splicing - minor pathways as enriched in shared genetic variation between chronotype and bipolar disorder.

2024-02-18

Abstract excerpt

It has been postulated that circadian dysfunction may contribute to the sleep problems prevalent in neurodevelopmental and neuropsychiatric conditions. Genetic correlations between numerous pairs of neurodevelopmental or neuropsychiatric and sleep phenotypes have been identified. We hypothesize that this overlapping genetic variation is enriched in certain biological pathways. We used genome-wide polygenic score a...

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Literature Corpus work: c8912aa2-f839-549b-8954-c8d2bf949c4e
DOI: 10.1101/2024.02.16.24302920

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