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Article

Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.

EBioMedicine - 1 Aug 2026

Żebrowska Magdalena, Wielscher Matthias, Zhang Jing, Saksvik-Lehouillier Ingvild, DiMilia Lee, Burns Angus, Valliere Jesse, Vincenzi Leonardo, Redline Susan, Okereke Olivia, Saxena Richa, Richmond Rebecca, Rutter Martin K, Schernhammer Eva S

Abstract excerpt

BACKGROUND: Circadian disruption affects multiple aspects of human health, but the genetic architecture of individual susceptibility remains unclear. We examined the genetics of the Circadian Imbalance Index (CII), an additive 0-5 score combining evening chronotype, short/long sleep, high neuroticism, atypical caffeinated coffee intake, and low vitamin D. METHODS: We ran a genome-wide association study (GWAS) of...

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Share to Circadian Rhythm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42481375
DOI: 10.1016/j.ebiom.2026.106380
PMCID: PMC13476902

Genes

CALCA
CRX
DHCR7
EEA1
EPHB1
HAL
KDM5A
PLEKHG7
SERPING1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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