Article

Early Immune Hypoactivation and Persistent Innate Reprogramming Characterize Chronic Chikungunya Disease

2026-06-26

Abstract excerpt

Chikungunya virus (CHIKV) infection causes acute febrile illness and debilitating arthralgia, with up to 40-80% of patients developing chronic chikungunya disease characterized by persistent arthralgia and fatigue lasting months to years. The immunological mechanisms underlying this transition remain poorly understood. We performed longitudinal immune profiling of CHIKV-infected patients stratified by clinical out...

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Literature Corpus work: 5da364e3-7a99-56c2-85ec-1ca5dfdf700b
DOI: 10.64898/2026.06.22.733701

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