Article

Histology-Aware Graph for Modeling Intercellular Communication in Spatial Transcriptomics

2026-01-23

Abstract excerpt

Cell-cell communication (CCC) is essential to how life forms and functions. Recent tools achieve single-cell-resolved CCC inference utilizing spatial transcriptomics (ST). However, most ignore the modeling of tissue contexts surrounding cells, causing high false-positive/negative rates. Here, we propose HARMONIC, a CCC inference method integrating multimodal ST and hematoxylin and eosin (H&E)-stained images. HARMO...

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Literature Corpus work: c825118e-71d1-5514-927e-2a5eb387050d
DOI: 10.64898/2026.01.22.701166

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