Article

Proximity-Aware Graph Attention Networks for Spatially Resolved Cell-Cell Inference

2026-04-23

Abstract excerpt

Cell-cell inference is a fundamental mechanism driving tissue homeostasis, immune regulation, and disease progression. Existing CCC inference tools operate on dissociated single-cell RNA-seq data, discarding the spatial constraints that govern short-range paracrine and juxtacrine signaling. We present S pa GNN, a proximity-aware graph attention network that jointly encodes physical cell adjacency and ligand-recep...

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Literature Corpus work: 7bb4b93d-d981-5906-a74b-b200bbe51c49
DOI: 10.64898/2026.04.20.719753

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