Article

Dual Targeting of FGFR3 and ERBB3 Enhances The Efficacy of FGFR Inhibitors in FGFR3 Fusion-Driven Bladder Cancer

2021-11-09

Abstract excerpt

<h4>Background: </h4> Mutations and fusions in Fibroblast Growth Factor Receptor 3 ( FGFR3) occur in 10-20% of metastatic urothelial carcinomas and confers sensitivity to FGFR inhibitors. However, responses to these agents are often short-lived due to the development of acquired resistance. The objective of this study was to identify mechanisms of resistance to FGFR inhibitors in two previously uncharacterised bla...

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Literature Corpus work: c812a1ed-b998-5e7f-b431-16b909ebad24
DOI: 10.21203/rs.3.rs-1026540/v1

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