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Resistance to Selective FGFR Inhibitors in FGFR- Driven Urothelial Cancer

28 Jun 2023

Abstract excerpt

Several fibroblast growth factor receptor (FGFR) inhibitors are approved or in clinical development for the treatment of FGFR-driven urothelial cancer, and molecular mechanisms of resistance leading to patient relapses have not been fully explored. We identified 21 patients with FGFR-driven urothelial cancer treated with selective FGFR inhibitors and analyzed postprogression tissue and/or circulating tumor DNA...

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PMID: 37377403
DOI: 10.1158/2159-8290.cd-22-1441

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