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Article

Oncogenic FGFR3 gene fusions in bladder cancer

21 Nov 2012

Abstract excerpt

FGF receptor 3 (FGFR3) is activated by mutation or over-expression in many bladder cancers. Here, we identify an additional mechanism of activation via chromosomal re-arrangement to generate constitutively activated fusion genes. FGFR3-transforming acid coiled coil 3 (TACC3) fusions resulting from 4p16.3 re-arrangements and a t(4;7) that generates a FGFR3-BAI1-associated protein 2-like 1 (BAIAP2L1) fusion were...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 23175443
DOI: 10.1093/hmg/dds486

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