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Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA Sequencing

29 Dec 2023

Abstract excerpt

Cancer stem cells (CSC) play a critical role in metastasis, relapse, and therapy resistance in colorectal cancer. While characterization of the normal lineage of cell development in the intestine has led to the identification of many genes involved in the induction and maintenance of pluripotency, recent studies suggest significant heterogeneity in CSC populations. Moreover, while many canonical colorectal cancer...

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PMID: 38156967
DOI: 10.1158/1541-7786.mcr-23-0468

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