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Article

The effects of ush2a gene knockout on vesicle transport in photoreceptors.

Gene - 20 Jan 2024

Han Shanshan, Wang Qiong, Cheng Meiqi, Hu Yue, Liu Pei, Hou Wanle, Liang Liang

Abstract excerpt

USH2A (Usher syndrome type 2A) gene mutations are the predominant cause of Usher syndrome type 2, characterized by sensorineural hearing loss and retinitis pigmentosa (RP), and also significant contributors to non-syndromic RP. To date, there is a lack of definitive therapeutic interventions to mitigate the associated disorders caused by USH2A mutations, and the precise pathogenic mechanisms underlying their...

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Identifiers

PMID: 37813209
DOI: 10.1016/j.gene.2023.147885

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