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Article

Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2015

Gopal Suhasini R, Chen Daniel H-C, Chou Shih-Wei, Zang Jingjing, Neuhauss Stephan C F, Stepanyan Ruben, McDermott Brian M, Alagramam Kumar N

Abstract excerpt

Usher syndrome type III (USH3) is characterized by progressive loss of hearing and vision, and varying degrees of vestibular dysfunction. It is caused by mutations that affect the human clarin-1 protein (hCLRN1), a member of the tetraspanin protein family. The missense mutation CLRN1(N48K), which affects a conserved N-glycosylation site in hCLRN1, is a common causative USH3 mutation among Ashkenazi Jews. The...

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Share to Endodeoxyribonucleases
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss

Share to Postural Balance

Share to Sequence Analysis, Protein

Share to Synapses

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Source

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Identifiers

PMID: 26180195
DOI: 10.1523/JNEUROSCI.1096-15.2015
PMCID: PMC4502259

Genes

CLRN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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