Article

Body mass index is a mediumiator of the genetic association between STK39 and blood pressure in Mexican women

2022-03-16

Abstract excerpt

<h4>Background: </h4> Although obesity causally relates to hypertension, the underlying genetic mechanisms are not completely understood. STK39 gene, encoding the SPAK kinase, associates with both hypertension and body mass index (BMI). In a murine model, we previously showed that the inactivation of SPAK resulted in a hypotensive and obesity-resistant phenotype. Methods We analyzed the mediator effect of BMI on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c76d7145-9815-5bff-8351-bf5fd4868567
DOI: 10.21203/rs.3.rs-1328727/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Body mass index is a mediumiator of the genetic association between STK39 and blood pressure in Mexican womenDOI 10.21203/rs.3.rs-1328727/v1Read

STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.Semantic proximity Read

Expression of STK39 in peripheral blood of hypertension patients and the relationship between its genetic polymorphism and blood pressure.Semantic proximity Read

A meta-analytical assessment of STK39 three well-defined polymorphisms in susceptibility to hypertension.Semantic proximity Read

Hypertension mediated the effects of pericardial adipose tissue on cardiovascular diseasesSemantic proximity Read

Lack of association between STK39 and hypertension in the Chinese population.Semantic proximity Read

Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes.Semantic proximity Read

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.Semantic proximity Read

Association of ATP2B1 and STK39 gene variants with blood pressure levels in patients with essential hypertension.Semantic proximity Read

The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.Semantic proximity Read

-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies.Semantic proximity Read

Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.Semantic proximity Read

STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort.Semantic proximity Read