Article

Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neurons

2025-07-31

Abstract excerpt

Excitatory synapses are the most abundant synapse type in the brain. Being essential for behaviour and are implicated in hundreds of brain disorders, these synapses exhibit striking structural and functional diversity. Synaptome mapping at single-synapse resolution reveals that synaptic protein diversity is spatially organised along the dendritic tree of individual neurons and varies with age and cell-type. Howeve...

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Literature Corpus work: e57858c9-8cfc-5e02-b287-29d94f200fc7
DOI: 10.1101/2025.07.31.667853

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