Article

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells

2022-04-16

Abstract excerpt

<h4>Background & Aims</h4> RET receptor tyrosine kinase is necessary for enteric nervous system (ENS) development. Loss-of-function RET mutations cause Hirschsprung disease (HSCR), in which infants are born with aganglionic bowel. Despite surgical correction, HSCR patients often experience chronic defecatory dysfunction and enterocolitis, suggesting that RET is important after development. To test this hypothesi...

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Literature Corpus work: c6e8e656-dbf3-5146-98ad-7cb3d51dcf34
DOI: 10.1101/2022.04.15.488514

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