Article

VopU is a novel T3SS effector protein with mono-ADP-ribosyltransferase activity and a non-canonical H-Y-Q catalytic triad

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Vibrio parahaemolyticus utilizes its second Type III Secretion System (T3SS2) to deliver a suite of effector proteins that subvert eukaryotic host cell processes. In this study, we characterize VPA1312, renamed VopU, as a novel T3SS2 effector. We demonstrate that VopU is translocated into infected cells via the T3SS2 and independently of the VocC chaperone. From bioinformatic analyses, VopU is a...

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Literature Corpus work: 4174c730-5a9c-5887-9ff0-4e72ec3ea764
DOI: 10.64898/2026.05.07.723553

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