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Article

Characterization of C3larvinA, a novel RhoA-targeting ADP-ribosyltransferase toxin produced by the honey bee pathogen, Paenibacillus larvae.

Bioscience reports - 31 Jan 2020

Turner Madison, Tremblay Olivier, Heney Kayla A, Lugo Miguel R, Ebeling Julia, Genersch Elke, Merrill A Rod

Abstract excerpt

C3larvinA is a putative virulence factor produced by Paenibacillus larvae enterobacterial-repetitive-intergenic-consensus (ERIC) III/IV (strain 11-8051). Biochemical, functional and structural analyses of C3larvinA revealed that it belongs to the C3-like mono-ADP-ribosylating toxin subgroup. Mammalian RhoA was the target substrate for its transferase activity suggesting that it may be the biological target of...

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Identifiers

PMID: 31844879
DOI: 10.1042/BSR20193405
PMCID: PMC6954368

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Source receipt: pubmed, retrieved 7 Sept 2026.

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