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Article

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Scientific reports - 3 Feb 2016

Medina-Carmona Encarnación, Palomino-Morales Rogelio J, Fuchs Julian E, Padín-Gonzalez Esperanza, Mesa-Torres Noel, Salido Eduardo, Timson David J, Pey Angel L

Abstract excerpt

Protein dynamics is essential to understand protein function and stability, even though is rarely investigated as the origin of loss-of-function due to genetic variations. Here, we use biochemical, biophysical, cell and computational biology tools to study two loss-of-function and cancer-associated polymorphisms (p.R139W and p.P187S) in human NAD(P)H quinone oxidoreductase 1 (NQO1), a FAD-dependent enzyme which...

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Identifiers

PMID: 26838129
DOI: 10.1038/srep20331
PMCID: PMC4738246

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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