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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

25 Jul 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout...

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PMID: 35879412
DOI: 10.1038/s41588-022-01131-x

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