Article

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2

2025-11-17

Abstract excerpt

<title>Abstract</title> <p> SARS-CoV-2 is a positive-sense RNA virus and was responsible for the devastating COVID-19 pandemic. Although the current disease burden is less severe, there are limited treatment options, significant gaps in knowledge, and a looming threat of the emergence of variants and future pandemics. To address these challenges, we performed genome-wide CRISPR knockout screens in a novel human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ba6c2a2-94e3-5e08-ae81-707c4f7157b5
DOI: 10.21203/rs.3.rs-7871130/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2DOI 10.21203/rs.3.rs-7871130/v1Read

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2Semantic proximity Read

Systematic Genome-Scale Identification of Host Factors for SARS-CoV-2 Infection Across Models Yields a Core Single Gene Dependency; <i>Ace2</i>Semantic proximity Read

Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; <i>ACE2</i>Semantic proximity Read

Genome-scale CRISPR screens identify host factors that promote human coronavirus infectionSemantic proximity Read

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factorsSemantic proximity Read

Genome-scale CRISPR Screens Identify Host Factors that Promote Human Coronavirus InfectionSemantic proximity Read

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsSemantic proximity Read

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concernSemantic proximity Read

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targetsSemantic proximity Read

Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infectionSemantic proximity Read

Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infectionSemantic proximity Read

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronavirusesSemantic proximity Read