Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.

Nature - 28 Nov 1996

Neumann S, Doubell T P, Leslie T, Woolf C J

Abstract excerpt

Pain is normally evoked only by stimuli that are sufficiently intense to activate high-threshold A(delta) and C sensory fibres, which relay the signal to the spinal cord. Peripheral inflammation leads to profoundly increased pain sensitivity: noxious stimuli generate a greater response and stimul...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Inflammation
Share to Nerve Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurons, Afferent

Share to Phenotype

Share to Rats, Sprague-Dawley

Share to Spinal Cord

Source

Identifiers

PMID: 8934522
DOI: 10.1038/384360a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8934522-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.PMID 8934522Read ↗

Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesiaSemantic proximity Read ↗

Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.Semantic proximity Read ↗

Deconstructing the neuropathic pain phenotype to reveal neural mechanisms.Semantic proximity Read ↗

Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.Semantic proximity Read ↗

Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain.Semantic proximity Read ↗

P2X4R+ microglia drive neuropathic pain.Semantic proximity Read ↗

Nociceptors--noxious stimulus detectors.Semantic proximity Read ↗

The interplay between M1/M2 macrophages and sensory neurons in pain modulationSemantic proximity Read ↗

Neuraxial Cytokines in Pain States.Semantic proximity Read ↗

The variability of nociplastic and central pain definition in literature: a scoping reviewSemantic proximity Read ↗

Macrophage as a Peripheral Pain Regulator.Semantic proximity Read ↗

The impact of inflammation on bronchial neuronal networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.