Article

Evaluating the consequences of childhood adiposity on the human plasma proteome at three timepoints across the lifecourse

2025-06-23

Abstract excerpt

Applying a lifecourse approach using human genetic data, we sought to evaluate the effect of childhood adiposity on the circulating proteome using measurements taken at three key life stages. We found genetically predicted childhood adiposity to have an effect on 8 proteins measured during childhood (mean age: 9.9 years) including TNFSF11 which is involved in T cell-dependent immune response. Using a mediation fra...

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Literature Corpus work: c62a05aa-72e3-5e82-9495-8755e30fa398
DOI: 10.1101/2025.06.20.25329991

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