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Article

Plasma proteome variation and its genetic determinants in children and adolescents.

Nature genetics - 1 Mar 2025

Niu Lili, Stinson Sara Elizabeth, Holm Louise Aas, Lund Morten Asp Vonsild, Fonvig Cilius Esmann, Cobuccio Leonardo, Meisner Jonas, Juel Helene Bæk, Fadista Joao, Thiele Maja, Krag Aleksander, Holm Jens-Christian, Rasmussen Simon, Hansen Torben, Mann Matthias

Abstract excerpt

Our current understanding of the determinants of plasma proteome variation during pediatric development remains incomplete. Here, we show that genetic variants, age, sex and body mass index significantly influence this variation. Using a streamlined and highly quantitative mass spectrometry-based proteomics workflow, we analyzed plasma from 2,147 children and adolescents, identifying 1,216 proteins after quality...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39972214
DOI: 10.1038/s41588-025-02089-2
PMCID: PMC11906355

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