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Article

Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines.

Trends in genetics : TIG - 1 Jul 2021

Roy Sudipto

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is a common skeletal disorder, characterized by abnormal spine curvatures. In zebrafish, cilia-driven cerebrospinal fluid flow and urotensin II pathway activity are required for proper spine morphogenesis. Genetic studies with AIS patients now establish a conservation of the zebrafish findings in the etiology of the disease.

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Identifiers

PMID: 33858671
DOI: 10.1016/j.tig.2021.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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