Article

Pre-clinical models of idiopathic scoliosis implicate sex-specific roles for complement activity in modulating spinal curve severity

2026-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic scoliosis (IS) is the most common spinal deformity and disproportionately affects adolescent females with severe disease. Although its etiology remains unclear, increasing evidence implicates inflammatory pathways in spinal curve progression. The complement cascade, a central component of innate immunity, has been linked to IS, but its functional role has not been directly tested. Her...

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Literature Corpus work: 3de657e9-069d-5764-878d-b809766c9f24
DOI: 10.64898/2026.02.20.707049

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