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Article

Inflammation Aggravates Disease Severity in Marfan Syndrome Patients

30 Mar 2012

Abstract excerpt

BACKGROUND: Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addressed so far. METHODOLOGY/PRINCIPAL FINDINGS: Here we showed that both TGF-β and inflammation are up-regulated in...

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PMID: 22479353
DOI: 10.1371/journal.pone.0032963

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