Article

Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

2024-09-07

Abstract excerpt

<h4>Summary</h4> The yellow fever virus 17D (YFV-17D) live attenuated vaccine is considered one of the successful vaccines ever generated associated with high antiviral immunity, yet the signaling mechanisms that drive the response in infected cells are not understood. Here, we provide a molecular understanding of how metabolic stress and innate immune responses are linked to drive type I IFN expression in respon...

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Literature Corpus work: c5b33435-cc81-5663-8bbf-90afb71732a3
DOI: 10.1101/2024.09.04.611167

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