Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication

Abstract excerpt

Pseudorabies virus (PRV) utilizes multiple strategies to inhibit type I interferon (IFN-I) production and signaling to achieve innate immune evasion. Among several other functions, mitochondria serve as a crucial immune hub in the initiation of innate antiviral responses. It is currently unknown whether PRV inhibits innate immune responses by manipulating mitochondria. In this study, we found that PRV infection...

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• Autophagy in Disease and Therapy
• Mosquito-borne diseases and control
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