Article
Insertional mutation of 'classical' and novel genes in transgenic mice.
Trends in genetics : TIG - 1 Oct 1992
Meisler M H
Abstract excerpt
Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited disorders and developmental abnormalities.
Topics
- Animals
- Female
- Male
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Phenotype