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Article

Analysis of the promoter region of the interleukin-2 receptor alpha chain (CD25) gene in human B lymphocytes

1999-01-01

Abstract excerpt

In T and B cells, attenuation of an undefined negative regulatory element binding protein (NRE-BP) binding to a negative regulatory element (NRE) removes the suppression of transcriptional activity upon the promoter of a unique 55kDa IL-2 receptor subunit, CD25. This event leads to the expression of CD25 at the cell surface. In human B cells IL-4, a potent activator of CD25 transcription abolishes ISIRE binding ac...

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Literature Corpus work
c594217f-24ac-5909-89c3-851cf4875272
DOI
10.5525/gla.thesis.71277
Open publication

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Analysis of the promoter region of the interleukin-2 receptor alpha chain (CD25) gene in human B lymphocytesDOI 10.5525/gla.thesis.71277
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