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Article

Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty.

The Journal of clinical endocrinology and metabolism - 1 Jun 2016

Idkowiak Jan, Taylor Angela E, Subtil Sandra, O'Neil Donna M, Vijzelaar Raymon, Dias Renuka P, Amin Rakesh, Barrett Timothy G, Shackleton Cedric H L, Kirk Jeremy M W, Moss Celia, Arlt Wiebke

Abstract excerpt

CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA. Deficient DHEA sulfation, the opposite enzymatic reaction to that catalyzed by STS, results in androgen excess by increased conversion of DHEA to active androgens. STS deficiency (STSD) due to deletions or...

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Identifiers

PMID: 27003302
DOI: 10.1210/jc.2015-4101
PMCID: PMC4891801

Genes

STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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