Article

Integrated Host-Microbe Signatures Differentiate Respiratory Infection from Incidental Pathogen Carriage

2025-10-28

Abstract excerpt

Accurately distinguishing lower respiratory tract infection (LRTI) from incidental pathogen carriage (IPC) is clinically challenging. The host immunologic and microbial factors that define the states of LRTI and IPC are poorly understood. We performed host-microbe metatranscriptomic profiling of tracheal aspirate from 326 mechanically ventilated children with clinically adjudicated LRTI (n=207), IPC (n=70), or non...

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Literature Corpus work: c56ecca7-122e-58fc-ad3e-ae6ddde8a7e3
DOI: 10.1101/2025.10.27.25338902

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