Article

Host–Microbiome Archetypes Differentiate Infection from Pathogen Carriage in the Human Lower Airway

2025-12-01

Abstract excerpt

<title>Abstract</title> <p> Accurately distinguishing lower respiratory tract infection (LRTI) from incidental pathogen carriage (IPC) is clinically challenging. The host immunologic and microbial factors that define the states of LRTI and IPC are poorly understood. We performed host-microbe metatranscriptomic profiling of tracheal aspirate from 326 mechanically ventilated children with clinically adjudicated LR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9e14232-83a8-51a7-bf29-cceaadb45732
DOI: 10.21203/rs.3.rs-8171822/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host–Microbiome Archetypes Differentiate Infection from Pathogen Carriage in the Human Lower AirwayDOI 10.21203/rs.3.rs-8171822/v1Read

Integrated Host-Microbe Signatures Differentiate Respiratory Infection from Incidental Pathogen CarriageSemantic proximity Read

Integrated Host/Microbe Metagenomics Enables Accurate Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenSemantic proximity Read

Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill AdultsSemantic proximity Read

Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill AdultsSemantic proximity Read

Pathogen spectrum and microbiome in lower respiratory tract of patients with different pulmonary diseases based on metagenomic next-generation sequencingSemantic proximity Read

Respiratory Microbiome Profiling for Etiologic Diagnosis of Pneumonia in Mechanically Ventilated PatientsSemantic proximity Read

Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcomeSemantic proximity Read

Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severitySemantic proximity Read

Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and diseaseSemantic proximity Read

Microbial Dynamics and Pulmonary Immune Responses in COVID-19 Secondary Bacterial PneumoniaSemantic proximity Read

Immune and microbial signatures in immunocompetent and immunocompromised patients with pneumoniaSemantic proximity Read

A Four-Gene Signature from Blood to Exclude Bacterial Etiology of Lower Respiratory Tract Infection in AdultsSemantic proximity Read