Article

Integrated Host/Microbe Metagenomics Enables Accurate Lower Respiratory Tract Infection Diagnosis in Critically Ill Children

2022-12-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Lower respiratory tract infection (LRTI) is a leading cause of death in children worldwide. LRTI diagnosis is challenging since non-infectious respiratory illnesses appear clinically similar and existing microbiologic tests are often falsely negative or detect incidentally-carried microbes, resulting in antimicrobial overuse and adverse outcomes. Lower airway metagenomics has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 646cdff6-d222-525f-8217-24b9052a5e52
DOI: 10.1101/2022.12.01.22282994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Host/Microbe Metagenomics Enables Accurate Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenDOI 10.1101/2022.12.01.22282994Read

Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill AdultsSemantic proximity Read

Developing an Early Diagnostic Signature and Deciphering the Microbial-Host Dynamics in Lower Respiratory Tract Infection (LRTI) in Paediatric Intensive Care Unit (PICU) PatientsSemantic proximity Read

Host–Microbiome Archetypes Differentiate Infection from Pathogen Carriage in the Human Lower AirwaySemantic proximity Read

Integrated Host-Microbe Signatures Differentiate Respiratory Infection from Incidental Pathogen CarriageSemantic proximity Read

Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluid From Children With Severe Pneumonia in Pediatric Intensive Care UnitSemantic proximity Read

Clinical utility of metagenomic next-generation sequencing in pathogen detection for lower respiratory tract infectionsSemantic proximity Read

Metagenomic next-generation sequencing of bronchoalveolar lavage fluid from children with severe pneumonia in pediatric intensive care unitSemantic proximity Read

Metagenomic next-generation sequencing Reveals Respiratory Pathogen distribution in COVID-19Semantic proximity Read

Diagnostic value of metagenomic next-generation sequencing for bronchoalveolar lavage diagnostics in patients with lower respiratory tract infectionsSemantic proximity Read

Respiratory Tract Pathogen Detection in Children: Clinical Practice and Considerations of mNGS and tNGS TechnologiesSemantic proximity Read

A Four-Gene Signature from Blood to Exclude Bacterial Etiology of Lower Respiratory Tract Infection in AdultsSemantic proximity Read