Gene Regulatory Network Inference reveals <i>tcf4</i> as a key a player in neuroblastoma gene expression circuitry

Abstract excerpt

Neuroblastoma (NB), a pediatric cancer arising from disrupted sympathetic neuron differentiation, exhibits marked heterogeneity and limited therapeutic options. To better understand its molecular circuitry dynamics, we applied CardamomOT, a novel Gene Regulatory Network (GRN) inference framework, to single-cell RNA-seq data from patient-derived tumoroids. This approach models gene regulation via piecewise determin...

Topics

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• Adenocarcinoma of Lung
• Bayes Theorem
• Computational Biology
• Epistasis, Genetic
• Gene Expression Regulation, Neoplastic
• Markov Chains
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

e7551bbe-8af1-5491-97fc-d82cfb686f39

DOI

10.64898/2026.07.07.737136