Article

Insights in the Interaction of HPV-16 E6 and Its Variants (E-G350, E-A176/G350, E-C188/G350, AAa and AAc) with MAGI-1

2021-09-06

Abstract excerpt

Oncogenic protein E6 from Human Papilloma Virus 16 (HPV-16) mediates the degradation of Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI-1), throughout the interaction of its protein binding motif (PBM) with the Discs-large homologous regions 1 (PDZ1) domain of MAG1-1. Generic variation in the E6 gene that translates to changes in the protein’s amino acidic sequence modifies the in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4b877b7-7ab5-5b11-ad00-461a5c194e4b
DOI: 10.20944/preprints202109.0101.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insights in the Interaction of HPV-16 E6 and Its Variants (E-G350, E-A176/G350, E-C188/G350, AAa and AAc) with MAGI-1DOI 10.20944/preprints202109.0101.v1Read

Molecular Insights Into the Interaction of HPV-16 E6 Variants Against MAGI-1 PDZ1 DomainSemantic proximity Read

Virus-host protein-protein interactions between human papillomavirus 16 E6 A1 and D2/D3 sub-lineages: variances and similaritiesSemantic proximity Read

Virus-Host Protein-Protein Interactions between Human Papillomavirus 16 E6 A1 and D2/D3 Sub-Lineages: Variances and Similarities.Semantic proximity Read

Towards an understanding of the evolution of the HPV E6 PDZ binding motifSemantic proximity Read

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targetsSemantic proximity Read

Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex FormationSemantic proximity Read

A comprehensive study on identifying the structural and functional SNPs of human neuronal membrane glycoprotein M6A (GPM6A).Semantic proximity Read

In-Silico Molecular Modeling Studies to Identify Novel Potential Inhibitors of HPV E6 ProteinSemantic proximity Read

Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPVSemantic proximity Read

Structure of the p53 degradation complex from HPV16Semantic proximity Read

Computational insights of K1444N substitution in GAP-related domain of NF1 gene associated with neurofibromatosis type 1 disease: a molecular modeling and dynamics approach.Semantic proximity Read

HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation.Semantic proximity Read