Article
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation.
Oncogene - 6 Sept 2001
Thomas M, Glaunsinger B, Pim D, Javier R, Banks L
Abstract excerpt
It has recently been shown that the high-risk human papillomavirus (HPV) E6 proteins can target the PDZ-domain containing proteins, Dlg, MUPP-1, MAGI-1 and hScrib for proteasome-mediated degradation. However, the E6 proteins from HPV-16 and HPV-18 (the two most common high-risk virus types) differ in their ability to target these proteins in a manner that correlates with their malignant potential. To investigate...
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