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Article

Towards an understanding of the evolution of the HPV E6 PDZ binding motif

2020-01-01

Abstract excerpt

The high-risk human alpha papillomaviruses, associated with the development of cervical cancer differ in the carboxyl-terminal sequence of the E6 oncogenic protein, where a PDZ-binding motif (PBM) is located. The PBM binds to PDZ-containing proteins of the cell, and variation in the PBM sequence is likely to affect the PDZ protein selectivity of E6, and the phospho-acceptor site embedded within the PBM. Using the...

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Literature Corpus work
af87970c-d6b0-59de-83e5-0b1883ad76dc
DOI
10.21954/ou.ro.00011b51
Open publication

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Towards an understanding of the evolution of the HPV E6 PDZ binding motifDOI 10.21954/ou.ro.00011b51
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