Article

Early Lung Cancer Detection Using Nucleotide Transition Probabilities in plasma cell-free DNA

2025-09-12

Abstract excerpt

Lung cancer, the most lethal malignancy globally, urgently requires effective early detection methods. Current non-invasive approaches based on plasma cell-free DNA (cfDNA) fragmentomics are often constrained by limited sensitivity in early-stage patients due to low tumor DNA fraction. To overcome this, we introduce a novel computational feature—First-Order Transition Probability (FOTP)—to decode nucleotide sequen...

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Literature Corpus work: c49e455f-a6ea-5ef5-ad38-2c27fb1c3d81
DOI: 10.1101/2025.09.09.25335450

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