Article
Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis.
Stem cell research - 1 Sept 2013
Maumus Marie, Manferdini Cristina, Toupet Karine, Peyrafitte Julie-Anne, Ferreira Rosanna, Facchini Andrea, Gabusi Elena, Bourin Philippe, Jorgensen Christian, Lisignoli Gina, Noël Danièle
Abstract excerpt
Our work aimed at evaluating the role of adipose stem cells (ASC) on chondrocytes from osteoarthritic (OA) patients and identifying the mediators involved. We used primary chondrocytes, ASCs from different sources and bone marrow mesenchymal stromal cells (MSC) from OA donors. ASCs or MSCs were co-cultured with chondrocytes in a minimal medium and using cell culture inserts. Under these conditions, ASCs did not...
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