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Article

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action

6 Apr 2023

Abstract excerpt

Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA...

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PMID: 37089944
DOI: 10.3389/fphar.2023.1169019

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